Asymmetric division: Dynastic intricacies of neuroblast division
نویسنده
چکیده
The cytoplasmic determinants Numb and Prospero are distributed asymmetrically into the daughter cells of Drosophila neuroblasts. The proteins encoded by the genes inscuteable, staufen and miranda are involved in the localisation of Prospero.
منابع مشابه
MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions.
Asymmetric cell divisions produce all 302 neurons of the C. elegans hermaphrodite. Here, we describe a role for a C. elegans Dishevelled homolog, DSH-2, in an asymmetric neuroblast division. In dsh-2 mutants, neurons normally descended from the anterior neuroblast daughter of the ABpl/rpppa blast cell were frequently duplicated, while non-neuronal cells produced by the posterior daughter cell w...
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متن کاملCWN-1 functions with DSH-2 to regulate C. elegans asymmetric neuroblast division in a beta-catenin independent Wnt pathway.
In Caenorhabditis elegans, Wnt signaling regulates many asymmetric cell divisions. During embryogenesis, the C. elegans Dishevelled (Dsh) homolog, DSH-2, regulates asymmetric neuroblast division of the ABpl/rpppa blast cell. Dsh is a key intracellular component of both beta-catenin dependent and beta-catenin independent Wnt pathways. In C. elegans, most of the well-characterized asymmetric cell...
متن کاملCWN-1 functions with DSH-2 to regulate C. elegans asymmetric neuroblast division in a β-catenin independent Wnt pathway
Article history: In Caenorhabditis elegans, W Received for publication 28 July 2008 Revised 14 January 2009 Accepted 17 January 2009 Available online 29 January 2009
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Neuroblasts are the precursors of the Drosophila central nervous system and undergo repeated physical and molecular asymmetric cell divisions. Live imaging of neuroblast lineages within intact Drosophila larval brains has dramatically improved our current understanding of basic cellular processes such as the establishment of cell polarity, spindle orientation, and cytokinesis. The analysis of m...
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ورودعنوان ژورنال:
- Current Biology
دوره 7 شماره
صفحات -
تاریخ انتشار 1997